Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a successful intracellular pathogen that is responsible for the highest mortality rate among diseases caused by bacterial infections.
During early interaction with the host innate cells, M. tuberculosis cell surface antigens interact with Toll like receptor 4 (TLR4) to activate the nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) canonical, and non-canonical inflammasome pathways.
NLRP3 inflammasome activation in the alveoli has been reported to contribute to the early inflammatory response that is needed for an effective anti-TB response through production of pro-inflammatory cytokines, including those of the Interleukin 1 (IL1) family.
However, overstimulation of the alveolar NLRP3 inflammasomes can induce excessive inflammation that is pathological to the host. Several studies have explored the use of medicinal plants and/or their active derivatives to inhibit excessive stimulation of the inflammasomes and its associated factors, thus reducing immunopathological response in the host.
This review describes the molecular mechanism of the NLRP3 inflammasome activation in the alveoli during M. tuberculosis infection.
Furthermore, the mechanisms of inflammasome inhibition using medicinal plant and their derivatives will also be explored, thus offering a novel perspective on the alternative control strategies of M. tuberculosis-induced immunopathology.
Adjunct n-3 Long-Chain Polyunsaturated Fatty Acid Treatment in Tuberculosis Reduces Inflammation and Improves Anemia of Infection More in C3HeB/FeJ Mice With Low n-3 Fatty Acid Status Than Sufficient n-3 Fatty Acid Status
Populations at risk for tuberculosis (TB) may have a low n-3 polyunsaturated fatty acid (PUFA) status. Our research previously showed that post-infection supplementation of n-3 long-chain PUFA (LCPUFA) in TB without TB medication was beneficial in n-3 PUFA sufficient but not in low-status C3HeB/FeJ mice.
In this study, we investigated the effect of n-3 LCPUFA adjunct to TB medication in TB mice with a low compared to a sufficient n-3 PUFA status. Mice were conditioned on an n-3 PUFA-deficient (n-3FAD) or n-3 PUFA-sufficient (n-3FAS) diet for 6 weeks before TB infection.
Post-infection at 2 weeks, both groups were switched to an n-3 LCPUFA [eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA)] supplemented diet and euthanized at 4- and 14- days post-treatment. Iron and anemia status, bacterial loads, lung pathology, lung cytokines/chemokines, and lung lipid mediators were measured.
Following 14 days of treatment, hemoglobin (Hb) was higher in the n-3FAD than the untreated n-3FAS group (p = 0.022), whereas the n-3FAS (drug) treated control and n-3FAS groups were not.
Pro-inflammatory lung cytokines; interleukin-6 (IL-6) (p = 0.011), IL-1α (p = 0.039), MCP1 (p = 0.003), MIP1- α (p = 0.043), and RANTES (p = 0.034); were lower, and the anti-inflammatory cytokine IL-4 (p = 0.002) and growth factor GMCSF (p = 0.007) were higher in the n-3FAD compared with the n-3FAS mice after 14 days.
These results suggest that n-3 LCPUFA therapy in TB-infected mice, in combination with TB medication, may improve anemia of infection more in low n-3 fatty acid status than sufficient status mice.
Furthermore, the low n-3 fatty acid status TB mice supplemented with n-3 LCPUFA showed comparatively lower cytokine-mediated inflammation despite presenting with lower pro-resolving lipid mediators.
Childhood Tuberculosis: An Under Prioritized Disease in Nepal
Globally, childhood tuberculosis constitutes up to 10% of overall tuberculosis cases. In Nepal, childhood tuberculosis has remained around 5.5% of overall tuberculosis cases and has remained stagnant over the years.
Moreover, our health system is focused on adult tuberculosis. Childhood tuberculosis has recently got its attention both at the national and international levels.
National Tuberculosis Program has been a successful program; however, more has to be done to track childhood tuberculosis progress. In this viewpoint, we discuss current initiatives taken by the government and the way forward for case detection and management of childhood tuberculosis in Nepal.
Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
Most Mycobacterium tuberculosis (Mtb) resistant to rifampicin (RIF) has mutations in the rpoB gene, while most Mtb resistant to isoniazid (INH) has mutations in the katG gene or inhA promoter.
We used gene chip technology to detect mutations in these genes to determine the resistance of Mtb to RIF and INH. A total of 4148 clinical specimens with sputum smear positivity for acid-fast bacilli (AFB) were detected.
Then, taking the results of the drug sensitivity test (DST) as the reference standard, the detection efficiency of sputum samples from different grades of positive smears was compared in detail.
We found that the sensitivity of the gene chip method for detecting sputum samples with a grade ≥ AFB 2 + was higher than that of sputum samples with a grade ≤ AFB 1 + (P < 0.05).
When the grade of the sample was ≤ AFB 1 +, the sensitivity of the gene chip method was 72.6% for RIF, 67.3% for INH, and 60.0% for MDR-TB. When the grade of the sample was ≥ AFB 2 +, the sensitivity of the gene chip method was 84.5% for RIF, 78.2% for INH, and 73.9% for MDR-TB.
The results show that gene chip technology can be directly used to diagnose drug-resistant tuberculosis in clinical specimens, and the diagnostic efficiency for the detection of sputum specimens with a grade ≥ AFB 2 + is better than that of other sputum specimens.
Early phase of effective treatment induces distinct transcriptional changes in Mycobacterium tuberculosis expelled by pulmonary tuberculosis patients
Effective treatment reduces a tuberculosis patient’s ability to infect others even before they test negative in sputum or culture. Currently, the basis of reduced infectiousness of the Mycobacterium tuberculosis (Mtb) with effective treatment is unclear.
We evaluated changes in aerosolized bacteria expelled by patients through a transcriptomic approach before and after treatment initiation (up to 14 days) by RNA sequencing. A distinct change in the overall transcriptional profile was seen post-treatment initiation compared to pretreatment, only when patients received effective treatment.
This also led to the downregulation of genes associated with cellular activities, cell wall assembly, virulence factors indicating loss of pathogenicity, and a diminished ability to infect and survive in new host cells. Based on this, we identified genes whose expression levels changed with effective treatment.
Monoclonal Anti-M. tuberculosis Heat Shock Protein 70 (hsp70/Dnak/ML2496) IgG |
HSP701-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Crassostrea gigas A-kinase anchor protein 7 isoform X2 |
1-CSB-EP2586DXQ(M)e1 |
Cusabio |
-
EUR 872.40
-
EUR 510.00
-
EUR 2331.60
-
EUR 1266.00
-
EUR 1602.00
-
EUR 615.60
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Crassostrea gigas A-kinase anchor protein 7 isoform X2 expressed in E.coli |
Crassostrea gigas A-kinase anchor protein 7 isoform X2 |
1-CSB-EP2586DXQ(M)f1 |
Cusabio |
-
EUR 733.20
-
EUR 370.80
-
EUR 2192.40
-
EUR 1126.80
-
EUR 1461.60
-
EUR 476.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Crassostrea gigas A-kinase anchor protein 7 isoform X2 expressed in E.coli |
DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 70 nm |
GCK-M-70 |
Creative Diagnostics |
1 kit |
EUR 908.4 |
Mycobacterium tuberculosis (M. tuberculosis) Antibody |
abx415707-1ml |
Abbexa |
1 ml |
EUR 727.2 |
|
Recombinant Mycobacterium Tuberculosis HSP Protein |
VAng-Yyj0063-10g |
Creative Biolabs |
10 µg |
EUR 2250 |
Description: Mycobacterium Tuberculosis, HSP, recombinant protein. |
Mouse HSP-70 ELISA Kit |
EMH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Human HSP-70 ELISA Kit |
EHH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Porcine HSP-70 ELISA Kit |
EPH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Rat HSP-70 ELISA Kit |
ERH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Rabbit HSP-70 ELISA Kit |
ERTH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Goat HSP-70 ELISA Kit |
EGTH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Bovine HSP-70 ELISA Kit |
EBH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Canine HSP-70 ELISA Kit |
ECH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Anserini HSP-70 ELISA Kit |
EAH0308 |
Abclonal |
96Tests |
EUR 625.2 |
Heat Shock Protein 70 (Goat HSP-70) Antibody |
abx414751-01mg |
Abbexa |
0.1 mg |
EUR 644.4 |
|
Monoclonal Anti-M. tuberculosis 10 Kda cultural filtrate protein (CFP10) IgG |
CFP101-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Monoclonal Anti-M. tuberculosis Rv1734 dormant protein from H37Rv strain IgG |
RV17341-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Monoclonal Anti-M. tuberculosis Rv2031 dormant protein from H37Rv strain IgG |
RV20311-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Monoclonal Anti-M. tuberculosis Rv2623 dormant protein from H37Rv strain IgG |
RV26231-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Monoclonal Anti-M. tuberculosis 10 Kda cultural filtrate protein (CFP10) IgG #2 |
CFP102-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-00635R1 |
ChemNorm |
96T |
EUR 553.2 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-00635R2 |
ChemNorm |
48T |
EUR 372 |
Chicken Heat Shock Protein 70,Hsp-70 ELISA Kit |
CN-00782C1 |
ChemNorm |
96T |
EUR 560.4 |
Chicken Heat Shock Protein 70,Hsp-70 ELISA Kit |
CN-00782C2 |
ChemNorm |
48T |
EUR 379.2 |
PoFAine Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-01298P1 |
ChemNorm |
96T |
EUR 548.4 |
PoFAine Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-01298P2 |
ChemNorm |
48T |
EUR 367.2 |
Human Heat Shock Protein 70 HSP-70 ELISA kit |
E01H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Human Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Heat Shock Protein 70 HSP-70 ELISA kit |
E01H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Human Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Heat Shock Protein 70 HSP-70 ELISA kit |
E01H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Human Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Chicken Heat Shock Protein 70, Hsp-70 ELISA Kit |
CSB-E11196Ch-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 70, Hsp-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Chicken Heat Shock Protein 70, Hsp-70 ELISA Kit |
1-CSB-E11196Ch |
Cusabio |
-
EUR 1160.40
-
EUR 7110.00
-
EUR 3760.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 70, Hsp-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Canine Heat Shock Protein 70 (HSP-70) ELISA Kit |
CSB-E15779c-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Canine Heat Shock Protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Canine Heat Shock Protein 70 (HSP-70) ELISA Kit |
1-CSB-E15779c |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Canine Heat Shock Protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Fish Heat Shock Protein 70(HSP-70)ELISA Kit |
CSB-E16327Fh-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Fish Heat Shock Protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Fish Heat Shock Protein 70(HSP-70)ELISA Kit |
1-CSB-E16327Fh |
Cusabio |
-
EUR 1080.00
-
EUR 6571.20
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Fish Heat Shock Protein 70(HSP-70) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Heat Shock Protein 70, HSP-70 ELISA Kit |
CSB-E08297h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Heat Shock Protein 70, HSP-70 ELISA Kit |
1-CSB-E08297h |
Cusabio |
-
EUR 1080.00
-
EUR 6571.20
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat heat shock protein 70, hSP-70 ELISA Kit |
CSB-E08308r-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 70, hSP-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat heat shock protein 70, hSP-70 ELISA Kit |
1-CSB-E08308r |
Cusabio |
-
EUR 1160.40
-
EUR 7110.00
-
EUR 3760.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 70, hSP-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Heat Shock Protein 70, Hsp-70 ELISA Kit |
CSB-E08311m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat Shock Protein 70, Hsp-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Heat Shock Protein 70, Hsp-70 ELISA Kit |
1-CSB-E08311m |
Cusabio |
-
EUR 1135.20
-
EUR 6938.40
-
EUR 3672.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Heat Shock Protein 70, Hsp-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Pig Heat Shock Protein 70, HSP-70 ELISA Kit |
CSB-E08317p-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Pig Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Pig Heat Shock Protein 70, HSP-70 ELISA Kit |
1-CSB-E08317p |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Pig Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Goat Heat Shock Protein 70(HSP-70) ELISA KIT |
CSB-E13381G-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Goat Heat Shock Protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Goat Heat Shock Protein 70(HSP-70) ELISA KIT |
1-CSB-E13381G |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Goat Heat Shock Protein 70(HSP-70) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Bovine Heat Shock Protein 70, HSP-70 ELISA Kit |
CSB-E13452B-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Bovine Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Bovine Heat Shock Protein 70, HSP-70 ELISA Kit |
1-CSB-E13452B |
Cusabio |
-
EUR 1080.00
-
EUR 6571.20
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Bovine Heat Shock Protein 70, HSP-70 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Sheep heat shock protein 70 (HSP-70) ELISA kit |
CSB-EQ027551SH-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Sheep heat shock protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Sheep heat shock protein 70 (HSP-70) ELISA kit |
1-CSB-EQ027551SH |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Sheep heat shock protein 70 (HSP-70) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Heat Shock Protein 70,Hsp-70 ELISA Kit |
CN-02741M1 |
ChemNorm |
96T |
EUR 548.4 |
Mouse Heat Shock Protein 70,Hsp-70 ELISA Kit |
CN-02741M2 |
ChemNorm |
48T |
EUR 367.2 |
Human Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-03554H1 |
ChemNorm |
96T |
EUR 567.6 |
Human Heat Shock Protein 70,HSP-70 ELISA Kit |
CN-03554H2 |
ChemNorm |
48T |
EUR 387.6 |
Rat heat shock protein 70,hSP-70 ELISA Kit |
CN-01863R1 |
ChemNorm |
96T |
EUR 538.8 |
Goat Heat Shock Protein 70 HSP-70 ELISA kit |
E06H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Goat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Heat Shock Protein 70 HSP-70 ELISA kit |
E06H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Goat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Heat Shock Protein 70 HSP-70 ELISA kit |
E06H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Goat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Heat Shock Protein 70 HSP-70 ELISA kit |
E08H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Canine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Heat Shock Protein 70 HSP-70 ELISA kit |
E08H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Canine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Heat Shock Protein 70 HSP-70 ELISA kit |
E08H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Canine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
E04H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
E04H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Heat Shock Protein 70 HSP-70 ELISA kit |
E04H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Heat Shock Protein 70 HSP-70 ELISA kit |
E07H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Heat Shock Protein 70 HSP-70 ELISA kit |
E07H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Heat Shock Protein 70 HSP-70 ELISA kit |
E07H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Heat Shock Protein 70 HSP-70 ELISA kit |
E03H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Heat Shock Protein 70 HSP-70 ELISA kit |
E03H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Heat Shock Protein 70 HSP-70 ELISA kit |
E03H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Heat Shock Protein 70 HSP-70 ELISA kit |
E02H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Heat Shock Protein 70 HSP-70 ELISA kit |
E02H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Heat Shock Protein 70 HSP-70 ELISA kit |
E02H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse HSP-70(Heat Shock Protein 70) ELISA Kit |
EM1137 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 23.438pg/ml |
Sheep HSP 70(Heat Shock Protein 70) ELISA Kit |
ESH0059 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Sheep;Sensitivity: 1.875 ng/ml |
Mouse Heat Shock Protein 70(Hsp-70)ELISA Kit |
GA-E0315MS-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Mouse Heat Shock Protein 70(Hsp-70)ELISA Kit |
GA-E0315MS-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
GA-E0089RB-48T |
GenAsia Biotech |
48T |
EUR 391.2 |
Rabbit Heat Shock Protein 70,HSP-70 ELISA Kit |
GA-E0089RB-96T |
GenAsia Biotech |
96T |
EUR 628.8 |
Human HSP-70(Heat Shock Protein 70) ELISA Kit |
EH3242 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.469 ng/ml |
Rat HSP-70(Heat Shock Protein 70) ELISA Kit |
ER1057 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml |
Human Heat Shock Protein 70 (HSP-70) CLIA Kit |
abx197110-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Mouse Heat Shock Protein 70 (HSP-70) CLIA Kit |
abx197111-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Rat Heat Shock Protein 70 (HSP-70) CLIA Kit |
abx197112-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Heat Shock Protein 70,HSP-70 ELISA Kit |
201-12-1814 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Monkey Heat Shock Protein 70 HSP-70 ELISA kit |
E09H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Heat Shock Protein 70 HSP-70 ELISA kit |
E09H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Heat Shock Protein 70 HSP-70 ELISA kit |
E09H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat HSP-70(Heat Shock Protein 70) ELISA Kit |
EG0033 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Goat ;Sensitivity: 0.469 ng/ml |
Human Heat Shock Protein 70(HSP-70)ELISA Kit |
GA-E1830HM-48T |
GenAsia Biotech |
48T |
EUR 346.8 |
Human Heat Shock Protein 70(HSP-70)ELISA Kit |
GA-E1830HM-96T |
GenAsia Biotech |
96T |
EUR 559.2 |
Rat heat shock protein 70(hSP-70)ELISA Kit |
GA-E0530RT-48T |
GenAsia Biotech |
48T |
EUR 447.6 |
Rat heat shock protein 70(hSP-70)ELISA Kit |
GA-E0530RT-96T |
GenAsia Biotech |
96T |
EUR 730.8 |
Guinea Pig HSP-70 ELISA Kit |
EGH0308 |
Abclonal |
96Tests |
EUR 625.2 |
M. Tuberculosis HSP70 Protein |
abx060544-100ug |
Abbexa |
100 ug |
EUR 1378.8 |
|
M. tuberculosis CFP10, Protein |
abx061400-100ug |
Abbexa |
100 ug |
EUR 961.2 |
|
M. tuberculosis ESAT6, Protein |
abx061402-100ug |
Abbexa |
100 ug |
EUR 910.8 |
|
Anti-Horse Whole Serum | RWS-70 |
RWS-70 |
Immunology Consultants Laboratory |
1.0 mL |
EUR 130 |
Description: Anti-Horse Whole Serum | RWS-70 | Immunology Consultants Laboratory Host: Rabbit Format: Whole Serum Product Type: Primary Antibody Antibody Clonality: Polyclonal |
Monoclonal Anti-M. tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2) IgG |
HSP651-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Guinea pig Heat Shock Protein 70 HSP-70 ELISA kit |
E05H0301-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Heat Shock Protein 70 HSP-70 ELISA kit |
E05H0301-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig Heat Shock Protein 70 HSP-70 ELISA kit |
E05H0301-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Guinea pig Heat Shock Protein 70 HSP-70 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
CLIA kit for Human HSP-70 (Heat Shock Protein 70) |
E-CL-H1153 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Human HSP-70 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
CLIA kit for Mouse HSP-70 (Heat Shock Protein 70) |
E-CL-M0375 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Mouse HSP-70 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
CLIA kit for Rat HSP-70 (Heat Shock Protein 70) |
E-CL-R0326 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Rat HSP-70 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Fish Heat Shock Protein 70 (HSP-70) |
KTE40016-48T |
Abbkine |
48T |
EUR 424.8 |
|
Description: Quantitative sandwich ELISA for measuring Fish Heat Shock Protein 70 (HSP-70) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Fish Heat Shock Protein 70 (HSP-70) |
KTE40016-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2702.4 |
|
Description: Quantitative sandwich ELISA for measuring Fish Heat Shock Protein 70 (HSP-70) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Fish Heat Shock Protein 70 (HSP-70) |
KTE40016-96T |
Abbkine |
96T |
EUR 686.4 |
|
Description: Quantitative sandwich ELISA for measuring Fish Heat Shock Protein 70 (HSP-70) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Anti-Acr1 (M. tuberculosis) Purified |
11-185-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-Tb10.4 (M. tuberculosis) Purified |
11-186-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-Tb10.3 (M. tuberculosis) Purified |
11-187-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-Acr2 (M. tuberculosis) Purified |
11-188-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-Ag85b (M. tuberculosis) Purified |
11-189-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-Tb7.7 (M. tuberculosis) Purified |
11-190-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Anti-GlcB (M. tuberculosis) Purified |
11-192-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
M. Tuberculosis 38 kDa Protein |
abx060636-100ug |
Abbexa |
100 ug |
EUR 978 |
|
Zmp1 M. tuberculosis Recombinant Protein |
90-361 |
ProSci |
50 ug |
EUR 752.1 |
Description: M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible in human for the regulation of the biological activity of many hormones and peptides and are involved in many important processes such as blood pressure regulation (Neprilysin or NEP1), cardiovascular development (Endothelin Converting Enzyme-1 or ECE-12), prevention of haemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopeptidases family that plays a key role in Mycobacterium tuberculosis pathogenicity with a still unknown mechanism. Recently, it was shown to suppress inflammasome activation by inhibiting caspase-1 activation, thus preventing processing of pro-IL-1beta into IL-1beta and the consequent phagosome maturation. |
Human heat shock protein 70(HSP-70) antibody (IgG) ELISA kit |
CSB-E14905h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Qualitativeindirect ELISA kit for measuring Human heat shock protein 70 (HSP-70) antibody (IgG) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human heat shock protein 70(HSP-70) antibody (IgG) ELISA kit |
1-CSB-E14905h |
Cusabio |
-
EUR 964.80
-
EUR 6118.80
-
EUR 3244.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Qualitativeindirect ELISA kit for measuring Human heat shock protein 70(HSP-70) antibody (IgG) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human heat shock protein 70(HSP-70) antibody (IgM) ELISA kit |
CSB-EQ028092HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human heat shock protein 70 (HSP-70) antibody (IgM) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human heat shock protein 70(HSP-70) antibody (IgM) ELISA kit |
1-CSB-EQ028092HU |
Cusabio |
-
EUR 964.80
-
EUR 6118.80
-
EUR 3244.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human heat shock protein 70(HSP-70) antibody (IgM) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
ELISA kit for Mouse HSP-70/HSPA9 (Heat Shock Protein 70) |
E-EL-M0619 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 452.4 |
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse HSP-70/HSPA9 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Porcine HSP-70/HSPA9 (Heat Shock Protein 70) |
E-EL-P0094 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 624 |
|
Description: A sandwich ELISA kit for quantitative measurement of Porcine HSP-70/HSPA9 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Rat HSP-70/HSPA9 (Heat Shock Protein 70) |
E-EL-R0479 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 452.4 |
|
Description: A sandwich ELISA kit for quantitative measurement of Rat HSP-70/HSPA9 (Heat Shock Protein 70) in samples from Serum, Plasma, Cell supernatant |
HSP-70 ELISA Kit| Rat Heat Shock Protein 70 ELISA Kit |
EF017814 |
Lifescience Market |
96 Tests |
EUR 826.8 |
HSP 70 ELISA Kit| Sheep Heat Shock Protein 70 ELISA Kit |
EF019541 |
Lifescience Market |
96 Tests |
EUR 826.8 |
HSP-70 ELISA Kit| Mouse Heat Shock Protein 70 ELISA Kit |
EF012810 |
Lifescience Market |
96 Tests |
EUR 826.8 |
GrpE HSP-70 Cofactor (HSP24) E.Coli Recombinant Protein |
PROTP09372 |
BosterBio |
Regular: 25ug |
EUR 380.4 |
Description: GrpE Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids and having a molecular mass of 21.8 kDa. ;The GrpE is purified by proprietary chromatographic techniques. |
HSP-70/HSPA9 ELISA Kit| Porcine Heat Shock Protein 70 ELISA Kit |
EF016612 |
Lifescience Market |
96 Tests |
EUR 826.8 |
Rabbit polyclonal antibody for M. tuberculosis |
4603 |
Virostat |
1 ml |
EUR 360.16 |
Description: This is FITC conjugated rabbit polyclonal antibody against M tuberculosis all antigens for WB, ELISA. |
Rabbit polyclonal antibody for M. tuberculosis |
4607 |
Virostat |
1 ml |
EUR 360.16 |
Description: This is Biotin conjugated rabbit polyclonal antibody against M tuberculosis all antigens for WB, ELISA. |
Mouse antibody for M. tuberculosis CFP10 |
5172 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against M tuberculosis CFP10 for WB, ELISA. |
Mouse antibody for M. tuberculosis ESAT6 |
5173 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against M tuberculosis ESAT6 for WB, ELISA. |
Mouse antibody for M. tuberculosis 38kDa |
5174 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against M tuberculosis 38kDa for WB, ELISA. |
Mouse antibody for M. tuberculosis Hsp65 |
5177 |
Virostat |
100 ug |
EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against M tuberculosis Hsp65 for WB, ELISA. |
The observations of the study open up avenues for further evaluating the changes in bacterial gene expression during the early phase of treatment as biomarkers for monitoring response to tuberculosis treatment regimens and provide means of identifying better correlates of Mtb transmission.