Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity

Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity

Earlier research in MRL+/+ mice recommend involvement of oxidative stress (OS) in trichloroethene (TCE)-mediated autoimmunity. Nonetheless, molecular mechanisms underlying the autoimmunity stay to be totally elucidated. Though toll-like receptors (TLRs) and Nuclear issue (erythroid-derived 2)-like2 (Nrf2) pathways are implicated in autoimmune ailments (ADs), interaction of OS, TLR and Nrf2 in TCE-mediated autoimmune response stays...