Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

Anaplastic giant cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, contains systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, main cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups remains to be unsatisfactory, and already in second line efficient remedy choices are missing. To establish genes defining ALCL cell state and dependencies, we right...

CheXaid: deep learning assistance for physician diagnosis of tuberculosis using chest x-rays in patients with HIV

CheXaid: deep learning assistance for physician diagnosis of tuberculosis using chest x-rays in patients with HIV

Tuberculosis (TB) is the main reason for preventable loss of life in HIV-positive sufferers, and but typically stays undiagnosed and untreated. Chest x-ray is usually used to help in prognosis, but this presents further challenges as a result of atypical radiographic presentation and radiologist shortages in areas the place co-infection is most typical. We...