BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC

BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and agonistic antibodies in opposition to TRAIL loss of life receptors (DR) can induce apoptosis preferentially in tumor cells whereas inflicting nearly no injury to regular cells. Nonetheless, their therapeutic potential is proscribed by occurring resistance in tumor cells, together with non-small cell lung most cancers (NSCLC). Thus, elucidation...