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Translating the Tuberculosis Research Agenda: Much Accomplished, but Much More to Be Done.

Translating the Tuberculosis Research Agenda: Much Accomplished, but Much More to Be Done.

February 3, 2021

Prediction of Multidrug-Resistant Tuberculosis Using Machine Learning Algorithms in SWAT, Pakistan

Prediction of Multidrug-Resistant Tuberculosis Using Machine Learning Algorithms in SWAT, Pakistan

September 28, 2021

Real-Time Spatial and Temporal Analysis of the Translocation of the Apoptosis-Inducing Factor in Cells

Vector & Virus

Real-Time Spatial and Temporal Analysis of the Translocation of the Apoptosis-Inducing Factor in Cells

November 16, 2021

Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells.

Vector & Virus

Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells.

October 5, 2021

neuroscience antibodies, Nociceptor neurons promote IgE class switch in B cells

Vector & Virus

Nociceptor neurons promote IgE class switch in B cells

November 16, 2021

Global trends of epidemiological research in livestock tuberculosis for the last four decades

Vector & Virus

Global trends of epidemiological research in livestock tuberculosis for the last four decades

February 3, 2021

Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.

Vector & Virus

Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.

October 5, 2021

Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of the disease, the challenge in collecting appropriate specimens, and the low sensitivity of smear microscopy and culture. Culture and Xpert MTB/RIF provide higher diagnostic yield in presumptive TB in adults than in children. Current study was designed to understand poor yield of diagnostic assays in children. Children with presumptive ITTB were subjected to gastric aspirates and induced sputum twice. Samples were tested by Ziehl-Neelsen stain, Xpert MTB/RIF-assay, and MGIT-960 culture. Subjects were grouped as Confirmed, Unconfirmed, and Unlikely TB, and classified as progressive primary disease (PPD, lung parenchymal lesion), and primary pulmonary complex (PPC, hilar lymphadenopathy) on chest X-ray. Of children with culture-positive TB 51/394 (12.9%), culture-negative TB 305 (77.4%), and unlikely TB 38 (9.6%), 9 (2.3%) were smear positive, while 95 (24.1%) were Xpert-MTB/RIF positive. Xpert-MTB/RIF detected 40/51 culture confirmed cases (sensitivity 78.4% and NPV 96.3%). Culture was positive in more children presenting as PPD (p < 0.04). In culture-negative TB group, Xpert positivity was seen in 31% of those with PPD and 11.9% in those with PPC (p < 0.001). Conclusion: Xpert-MTB/RIF improved diagnosis by 2-fold and increased detection of MDR-TB. Both liquid culture and Xpert-MTB/RIF gave higher yield in children with lung parenchymal lesions. Children with hilar lymphadenopathy without active lung parenchymal lesions had poor diagnostic yield even with sensitive nucleic acid amplification tests, due to paucibacillary/localized disease, suggesting possible utility of invasively collected samples in early diagnosis and treatment.

Vector & Virus

Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of...

September 28, 2021

Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases.

Vector & Virus

Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1...

October 5, 2021

Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens

Vector & Virus

Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens

October 5, 2021

CheXaid: deep learning assistance for physician diagnosis of tuberculosis using chest x-rays in patients with HIV

Vector & Virus

CheXaid: deep learning assistance for physician diagnosis of tuberculosis using chest x-rays in patients with...

September 27, 2021

western hybridization, Visualization of RNA Transcripts in Western Corn Rootworm (Diabrotica virgifera virgifera) and Plants by In Situ Hybridization

Vector & Virus

Visualization of RNA Transcripts in Western Corn Rootworm (Diabrotica virgifera virgifera) and Plants by In...

November 16, 2021

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