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igg1k, A Retrospective Study to Assess the Efficacy, Safety and Drug Survival of Secukinumab in Plaque Psoriasis Patients in China
annexin binding buffer

A Retrospective Study to Assess the Efficacy, Safety and Drug Survival of Secukinumab in Plaque...

Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of the disease, the challenge in collecting appropriate specimens, and the low sensitivity of smear microscopy and culture. Culture and Xpert MTB/RIF provide higher diagnostic yield in presumptive TB in adults than in children. Current study was designed to understand poor yield of diagnostic assays in children. Children with presumptive ITTB were subjected to gastric aspirates and induced sputum twice. Samples were tested by Ziehl-Neelsen stain, Xpert MTB/RIF-assay, and MGIT-960 culture. Subjects were grouped as Confirmed, Unconfirmed, and Unlikely TB, and classified as progressive primary disease (PPD, lung parenchymal lesion), and primary pulmonary complex (PPC, hilar lymphadenopathy) on chest X-ray. Of children with culture-positive TB 51/394 (12.9%), culture-negative TB 305 (77.4%), and unlikely TB 38 (9.6%), 9 (2.3%) were smear positive, while 95 (24.1%) were Xpert-MTB/RIF positive. Xpert-MTB/RIF detected 40/51 culture confirmed cases (sensitivity 78.4% and NPV 96.3%). Culture was positive in more children presenting as PPD (p < 0.04). In culture-negative TB group, Xpert positivity was seen in 31% of those with PPD and 11.9% in those with PPC (p < 0.001). Conclusion: Xpert-MTB/RIF improved diagnosis by 2-fold and increased detection of MDR-TB. Both liquid culture and Xpert-MTB/RIF gave higher yield in children with lung parenchymal lesions. Children with hilar lymphadenopathy without active lung parenchymal lesions had poor diagnostic yield even with sensitive nucleic acid amplification tests, due to paucibacillary/localized disease, suggesting possible utility of invasively collected samples in early diagnosis and treatment.
annexin binding buffer

Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of...

Is analysis of inflammatory biomarkers and lymphocyte subpopulations useful in prediction of tuberculosis treatment outcomes?
annexin binding buffer

Is analysis of inflammatory biomarkers and lymphocyte subpopulations useful in prediction of tuberculosis treatment outcomes?

neuroscience antibodies, Nociceptor neurons promote IgE class switch in B cells
annexin binding buffer

Nociceptor neurons promote IgE class switch in B cells

Corning Spin-X Filter Tube Filter
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Corning Spin-X Filter Tube Filter 25 Spin Tube Filter Pack

Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity
annexin binding buffer

Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity

Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens
annexin binding buffer

Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma
annexin binding buffer

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection
annexin binding buffer

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis...

Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis
annexin binding buffer

Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis

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Genome operob chasecm mycobacterium smegmatis Capilia Tauns
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