Archived Announcements & News and Updates
Archived Announcements
- We are pleased to make available the annotated Mycobacterium marinum genome sequence as reported in Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. M. marinum, a pathogen of fish and amphibians, is a close relative of M. tuberculosis, the etiologic agent of tuberculosis in humans. Analysis of the M. marinum genome reveals genome downsizing and lateral gene transfer in M. tuberculosis that allowed it to become a specialized pathogen of humans and primates, and facilitates better understanding of tuberculosis disease.
- We recently made enhancements to the quick search
function to
find Rfam
annotations, which allow identification of likely functional RNAs,
for
example riboswitches.
July 2008:
June 2008: We are pleased to announce that TBDB now holds data from a publication by Rustad et al. titled "The enduring hypoxic response of Mycobacterium tuberculosis". The DosR regulon is known to play a primary role in survival of hypoxia induced bacteriostasis in Mycobacterium tuberculosis. Based on the results presented in this paper the authors suggest a reassessment of the role of DosR and the initial hypoxic response in MTB physiology.
May 2008: 
TubercuList provides a complete dataset of DNA
and protein sequences derived from the paradigm
strain M. tuberculosis H37Rv, linked to the relevant
annotations and functional assignments, using
various criteria (gene names, location, keywords, etc.). Now TBDB
provides direct links to TubercuList from 'External Links' section
of a Gene Detail page. For an example of the new Gene Detail page
with a link to TubercuList,
visit RV2429.
February 2008: We are happy to announce that TBDB provides links from gene pages to the Tuberculosis Structural Genomics Consortium (TBSGC). Using this resource, you can find stuctural information as well as images for TB proteins.
Archived News and Updates
- TB's return comes with high costs: You might think tuberculosis hasn't been a problem since your grandparents' era, but the illness is making a worldwide comeback. Its costs of treatment and lost productivity are estimated at almost $3 billion a year. Listen to Frank Browning reports on NPR's Market Place.
- Aggressive TB treatment a success: Tuberculosis which is resistant to many current treatments can be overcome with aggressive therapy, research suggests.
- The New England Journal of Medicine: More than 60 percent of patients diagnosed with extensively drug-resistant TB (XDR-TB), a type of tuberculosis that is very difficult to treat were cured with aggressive drug treatment by a team of Peruvian doctors.
- Association calls on state to fund tb programs In recognition of World TB Day on March 24, the American Lung Association of California released troubling statewide tuberculosis (TB) statistics and called on the state to avert a resurgence of TB by funding prevention and control efforts.
- Deadly TB strain sweeps Kyrgyz prisons
- CNN:US citizen who prompted an international health crisis by traveling after being diagnosed with multi-drug resistant TB was released from the hospital July 26, 2007.
- PLos Pathogens: Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells