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News and Updates

  • Tuberculosis strain spread by the Canadian fur trade reveals stealthy approach of TB epidemic. A study published in PNAS by Pepperell et al. report how TB transmitted to Canadian Aboriginal populations during the fur trade era remained dormant for more than a century and later resulted in TB epidemics when the conditions were ripe.
  • The BCG World Atlas is an interactive web resource developed by a team at McGill University that provides detailed information on current and past BCG policies and practices for over 180 countries. The Atlas is designed to be a useful resource for clinicians, policymakers and researchers alike, providing information that may be helpful for better interpretation of TB diagnostics as well as design of new TB vaccines. A paper describing this Atlas was published in PLoS Medicine recently. [Watch video press release].
  • Whole-Genome sequencing and social network analysis tracks the cause of a recent tuberculosis outbreak in Canada to crack cocaine use as the major contributor, reports the February 24, 2011, issue of The New England Journal of Medicine.
  • A PNAS article titled "Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells" reports research conducted largely in vitro using mouse cells, suggests that stem cells recruited to sites of tuberculosis infection may suppress surrounding immune cells, thereby helping the bacterium establish a persistent infection. You may read a commentary on this new study in "TheScientist".

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TBDatabase (TBDB) makes available the tools and resources available at the Stanford Microarray Database and the Broad Institute.
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Please cite:
Galagan JE, Sisk P, Stolte C, Weiner B, Koehrsen M, Wymore F, Reddy TB, Zucker JD, Engles R, Gellesch M, Hubble J, Jin H, Larson L, Mao M, Nitzberg M, White J, Zachariah ZK, Sherlock G, Ball CA and Schoolnik GK. TB database 2010: overview and update. Tuberculosis. 90(4):225-35. doi: 10.1016/j.tube2010.03.010
Full text  |  PubMed

Reddy TB, Riley R, Wymore F, Montgomery P, Decaprio D, Engels R, Gellesch M, Hubble J, Jen D, Jin H, Koehrsen M, Larson L, Mao M, Nitzberg M, Sisk P, Stolte C, Weiner B, White J, Zachariah ZK, Sherlock G, Galagan JE, Ball CA, Schoolnik GK. TB database: an integrated platform for tuberculosis research. Nucleic Acids Res. doi: 10.1093/nar/gkn652
Full text  |  PubMed

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